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It has been also revealed that low-dose ursodeoxycholic acid (UDCA) blocks the production of cancer induced reactive oxygen species through the PKC signaling pathway, thereby inhibiting transcription factors AP-1 and NF-κ B, leading to the expression of pro-inflammatory cytokine TNF-α and reducing the consumption of cachexia (e.g., fat and skeletal muscle tissue loss) (Tschirner et al., 2012)
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