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Among the 61 shared ATF4-dependent transcripts, those involved in amino acid synthesis and transport, one-carbon metabolism, and aminoacyl tRNA charging often displayed comparable fold changes between insulin stimulation and tunicamycin treatment, while canonical genes of the ER stress response, such as Herpud1 and Ddit3/Chop, showed much greater induction with tunicamycin (Figure 1F)
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