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204 Asthmatic patients exhale increased LTE 4 during attacks, and in AERD, the 5-LO and LTC 4 synthase pathways are overactive, producing excessive leukotrienes

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Furthermore, transcriptomic profiling of RA-FLS demonstrates that LLDT-8 induces broad gene expression changes, particularly downregulating immune and inflammatory pathways (e.g., cytokine-cytokine receptor interaction and TNF signaling)