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The following are generally considered contraindications or conditions requiring additional clinical scrutiny: Known copper metabolism disorders, including Wilson's disease (characterized by pathological copper accumulation) and Menkes disease, as additional exogenous copper may worsen underlying copper dysregulation Active malignancy, as the pro-angiogenic effects of GHK-Cu (including VEGF pathway activation) have not been studied in cancer populations and could theoretically influence tumor vasculature Pregnancy and breastfeeding, as safety has not been established in these populations Known hypersensitivity to GHK-Cu, copper compounds, or excipients used in the compounded formulation Active, uncontrolled infections at or near the application site Side effects and safety considerations The GHK-Cu safety profile has been characterized in a limited number of studies