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10.1186/s12974-019-1572-7 14 ChenG.DuX.CuiJ.SongJ.XiongM.ZengX.et al (2024)

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The authors concluded that progesterone causes ovary-dependent, persistent vaginal cornification and hyperplastic changes in the vaginal and cervical epithelium, affects the incidence of these lesions in mice treated simultaneously with estradiol, and significantly increases the incidence of mammary tumours in mammary tumour-virus bearing mice (Jones & Bern, 1977)